FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis
Abstract Background FK506 (Tacrolimus) is an important immunosuppressant, produced by industrial biosynthetic processes using various Streptomyces species.Considering the complex structure of FK506, it is reasonable to expect complex regulatory networks controlling its biosynthesis.Regulatory elements, present in gene clusters can have a profound i